The Emperor of All Maladies
A Biography of Cancer
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The Emperor of All Maladies is a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years.
The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist.
From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease.
Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
A Biography of Cancer
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Read an Excerpt
Diseases desperate grown
By desperate appliance are relieved,
Or not at all.
Cancer begins and ends with people. In the midst of scientific abstraction, it is sometimes possible to forget this one basic fact. . . . Doctors treat diseases, but they also treat people, and this precondition of their professional existence sometimes pulls them in two directions at once.
On the morning of May 19, 2004, Carla Reed, a thirty-year-old kindergarten teacher from Ipswich, Massachusetts, a mother of... see more
Reading Group Guide
In The Emperor of All Maladies, Siddhartha Mukherjee offers a sweeping and erudite history of cancer—from its earliest incarnations in ancient texts up to recent and long-awaited breakthroughs in treatment. Populated by captivating characters, from the Persian Queen Atossa, who instructed her servant to cut out a malignant tumor in her breast, to Sidney Farber, whose tireless research into children’s leukemia ushered in the modern era of cancer research, and written in Mukherjee’s artful prose, The Emperor of All Maladies reads like a thrilling novel, with scientific triumphs and setbacks, personal rivalries and alliances. But set against the backdrop of changing politics and social values, it is also a history of human civilization seen through the prism of cancer, the world’s most pervasive, tenacious disease.
Questions and Topics for Discussion
1. Cancer is often described as a “modern” disease—yet its first description dates from 2500 B.C. In what sense, then, is cancer a disea see more